Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.
作者： Olivier Zugasti , Wilfrid Rul , Pierre Roux , Carole Peyssonnaux , Alain Eychene
DOI: 10.1128/MCB.21.19.6706-6717.2001
关键词: RAC1 、 Protein kinase B 、 Cdc42 GTP-Binding Protein 、 MAPK/ERK pathway 、 Cell biology 、 Anoikis 、 Biology 、 Kinase 、 Cancer research 、 CDC42 、 Signal transduction
摘要: Signals from the extracellular matrix are essential for the survival of many cell types. Dominant-negative mutants of two members of Rho family GTPases, Rac1 and Cdc42, mimic the …
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