Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer
作者： C. Duggan , T. Maguire , E. McDermott , N. O'Higgins , J. J. Fennelly
关键词: Cancer 、 Metastasis 、 Receptor 、 Cancer research 、 Mammary gland 、 Medicine 、 Breast cancer 、 Cell surface receptor 、 Urokinase receptor 、 Plasminogen activator
摘要: Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA mediates its action while attached to membrane-bound receptor (uPAR). In this investigation we show that uPAR levels correlate with human breast cancers. levels, however, do not other components of the system such as tissue-type (t-PA), PAI-1 or PAI-2. addition, showed no correlation tumor size, axillary-node status estrogen-receptor status. On basis an optimum cut-off point, patients cancers containing high had worse prognosis than low receptor. However, prognostic marker cancer, was strong uPA. Our results are consistent data from model systems suggesting both necessary for © 1995 Wiley-Liss, Inc.
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