The Role of Conventional Bronchoscopy in the Workup of Suspicious CT Scan Screen-Detected Pulmonary Nodules

摘要: Background: Up to 50% of the participants in CT scan lung cancer screening trials have at least one pulmonary nodule. To date, role conventional bronchoscopy workup suspicious screen-detected nodules is unknown. If a bronchoscopic evaluation could be eliminated, cost-effectiveness program enhanced and potential harms avoided. Methods: All consecutive with positive result on between April 2004 December 2008 were enrolled. The diagnostic sensitivity nega tive predictive value calculated level nodules. In 95% nodules, gold standard for outcome was based surgical resection specimens. Results: A total 318 lesions evaluated by 308 participants. mean ± SD diameter 14.6 8.7 mm, whereas only 2.8% >30 mm diameter. 13.5% (95% CI, 9.0%-19.6%); specificity, 100%; value, negative 47.6% 41.8%-53.5%). Of all cancers detected, 1% detected retrospectively invisible both low-dose IV contrast. Conclusion: Conventional white-light should not routinely recommended patients test results program. Trial registration: Nederlands Register; No.: ISRCTN63545820; URL: www.trialregister.nl.