Primary site and regional lymph node involvement are independent prognostic factors for early-stage extranodal nasal-type natural killer/T cell lymphoma

摘要: Nasal-type extranodal natural killer/T-cell lymphoma (ENKTCL) originates primarily in the nasal cavity or extra-nasal sites within upper aerodigestive tract. However, it is unclear whether primary site can serve as an independent prognostic factor varying clinical outcomes observed with different be attributed merely to their propensities of regional lymph node involvement. The aim this study was investigate implications and involvement patients early-stage nasal-type ENKTCL. To develop a nomogram, we reviewed data 215 consecutively diagnosed ENKTCL who were treated Sun Yat-sen University Cancer Center chemotherapy radiotherapy between 2000 2011. predictive accuracy discriminative ability nomogram determined using concordance index (C-index) calibration curve. 5-year overall survival (OS) progression-free (PFS) rates higher than those (OS: 68.2% vs. 46.0%, P = 0.030; PFS: 53.4% 26.6%, P = 0.010). OS PFS Ann Arbor stage IE IIE 66.3% 59.2%, P = 0.003; 51.4% 40.3%, P = 0.009). Multivariate analysis showed that age >60 years, ECOG performance status score ≥2, elevated lactate dehydrogenase (LDH) level, site, significantly associated lower rate; LDH rate. included based on multivariate analysis. curve good agreement predicted actual rates, C-indexes for 0.697 0.634, respectively. are factors followed by definitive radiotherapy.