Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat
作者： Esfandiar Heidarian , Mahmoud Rafieian-Kopaei
DOI: 10.3109/13880209.2013.777931
关键词: Toxicity 、 Biochemistry 、 Aspartate transaminase 、 Alanine transaminase 、 Vitamin C 、 Phytotherapy 、 Cynara scolymus 、 Malondialdehyde 、 Traditional medicine 、 Lipid peroxidation 、 Biology 、 Complementary and alternative medicine 、 Molecular medicine 、 Pharmacology 、 Drug discovery 、 Pharmaceutical Science 、 General Medicine
摘要: AbstractContext: Artichoke, Cynara scolymus L. (Asteraceae), has many natural antioxidants and multiple pharmacological actions. Recent studies have shown that it antitoxic activity.Objective: Lead (Pb) is a dangerous environmental toxicant induces broad range of dysfunctions in human. This study evaluated the protective effect hydroethanolic extract artichoke against altered biochemical parameters rats fed with lead-containing diet.Materials methods: Thirty-two were randomly divided into four groups. The first (control) group received standard diet. second, third fourth groups 500 mg lead/kg diet, diet plus 300 mg/kg b.w. daily, 1 mg vitamin C/100 g daily for 6 weeks, respectively. Serum lead, lipoprotein profile, ALT (alanine transaminase), AST (aspartate ALP (alkaline phosphatase), malondialdehyde (MDA) liver histopathology assessments conducted.Results: lea...
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