Response of lead-induced oxidative stress and alterations in biogenic amines in different rat brain regions to combined administration of DMSA and MiADMSA

摘要: The present study was planned to investigate if combined administration of meso-2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA (MiADMSA) could achieve better recovery in the altered biochemical parameters suggestive brain oxidative stress depletion lead from blood following acute exposure. Male Wistar rats were exposed nitrate (50 mg/kg, i.p., once daily for 5 days) followed by treatment with above chelating agents using two different doses 25 or 50 mg/kg (orally) either alone combination five consecutive days. Lead exposure resulted significant inhibition delta-aminolevulinic dehydratase activity glutathione (GSH) blood. These changes accompanied reduction hemoglobin, RBC levels superoxide dismutase catalase activities. Significant increase reactive oxygen species (ROS) thiobarbituric substances (TBARS) noted. We observed marked ROS level while GSH/oxidized ratio showed decrease a concentration. norepinephrine, dopamine serotonin regions also on Co-administration MiADMSA particularly at lower dose most effective lead-induced hematological variables more pronounced compared monotherapy these chelators. On other hand, mg/kg) (25 each) had additional beneficial effect over individual agent biogenic amines. suggests that is generally chelator than might be option least removal target tissues.