Vaccines for otitis media: proposals for overcoming obstacles to progress.

作者: Timothy F. Murphy , Lauren O. Bakaletz , Jennelle M. Kyd , Bracie Watson , David L. Klein

DOI: 10.1016/J.VACCINE.2004.12.014

关键词: VaccinationOtitisImmunologyIntensive care medicineMiddle ear diseaseMedicine

摘要: Otitis media is a common problem with enormous morbidity worldwide. The development of vaccines to prevent otitis would have an important human and economic impact. A striking lack progress in the development, production clinical testing has occurred past decade. This review outlines series specific proposals intended advance vaccine for media.

参考文章(68)
BRUCE FIREMAN, STEVEN B. BLACK, HENRY R. SHINEFIELD, JANELLE LEE, EDWIN LEWIS, PAULA RAY, Impact of the pneumococcal conjugate vaccine on otitis media. Pediatric Infectious Disease Journal. ,vol. 22, pp. 10- 16 ,(2003) , 10.1097/00006454-200301000-00006
Mary M. Aspin, Alejandro Hoberman, James McCarty, Samuel E. McLinn, Stephen Aronoff, David J. Lang, Antonio Arrieta, Comparative study of the safety and efficacy of clarithromycin and amoxicillin-clavulanate in the treatment of acute otitis media in children. The Journal of Pediatrics. ,vol. 125, pp. 136- 141 ,(1994) , 10.1016/S0022-3476(94)70140-7
Jennelle Kyd, Anna John, Allan Cripps, Timothy F Murphy, Investigation of mucosal immunisation in pulmonary clearance of Moraxella (Branhamella) catarrhalis Vaccine. ,vol. 18, pp. 398- 406 ,(1999) , 10.1016/S0264-410X(99)00262-5
Mark A. Del Beccaro, Paul M. Mendelman, Andrew F. Inglis, Mark A. Richardson, Newton O. Duncan, Carla R. Clausen, Terrence L. Stull, Bacteriology of acute otitis media: a new perspective. The Journal of Pediatrics. ,vol. 120, pp. 81- 84 ,(1992) , 10.1016/S0022-3476(05)80605-5
Daniel J Morton, Lauren O Bakaletz, Joseph A Jurcisek, Timothy M VanWagoner, Thomas W Seale, Paul W Whitby, Terrence L Stull, Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media. Microbial Pathogenesis. ,vol. 36, pp. 25- 33 ,(2004) , 10.1016/J.MICPATH.2003.08.007
Stephen M Weber, Kenneth M Grundfast, Modern management of acute otitis media Pediatric Clinics of North America. ,vol. 50, pp. 399- 411 ,(2003) , 10.1016/S0031-3955(03)00025-7