The role of leptin in obesity and the potential for leptin replacement therapy.
作者： Helin Feng , Lihua Zheng , Zhangying Feng , Yaheng Zhao , Ning Zhang
DOI: 10.1007/S12020-012-9865-Y
关键词: Orexigenic 、 Leptin 、 Biology 、 Hypothalamus 、 Neuropeptide 、 Adipokine 、 Appetite 、 Leptin receptor 、 Internal medicine 、 Receptor 、 Endocrinology
摘要: Leptin (from the Greek word "lepto'' meaning "thin") is a 167-amino acid peptide hormone encoded by obesity (ob) gene and secreted white adipocytes. Blood leptin concentrations are increased in obese individuals. satiety that provides negative feedback to hypothalamus, controlling appetite energy expenditure. binds presynaptic GABAergic neurons produce its effect, raising distinct possibility axon terminals ultimate subcellular site of action for effects. Released into circulation, crosses blood-brain barrier receptors, influencing activity various hypothalamic neurons, as well encoding orexigenic anorexigenic neuropeptides. Moreover, affects wide range metabolic functions peripheral tissue. In this review, we discuss some physiologic leptin, including effects on replacement therapy.
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