Survival of baboon platelets labeled with diazotized (125-1)-iodosulfanilic acid: No effect of drugs that modify platelet behavior
作者： Stephen R. Hanson , Laurence A. Harker
DOI: 10.1016/0049-3848(81)90246-2
关键词: Cytoplasm 、 Glycoprotein 、 In vivo 、 Biochemistry 、 Platelet membrane glycoprotein 、 Baboon 、 Kinetics 、 Platelet 、 Dextran 、 Internal medicine 、 Endocrinology 、 Chemistry 、 Hematology
摘要: A baboon animal model has been developed to study the kinetics of platelets doubly labeled with 51-Cr, a cytoplasmic label, and diazotized 125-I-iodosulfanilic acid (D 125-ISA), which binds glycoprotein components platelet membrane. This was undertaken evaluate possible usefulness this extend primates previous observations D 125-ISA-labeled in rabbits. 125-ISA-platelet activity disappeared exponentially mean t12 0.90 days ± 0.11. Labeling 51-Cr-platelets 125-ISA resulted modest but significant reduction baseline 51-Cr-platelet survival time (from 5.5 0.2 4.7 0.4; p < 0.02). 51-Cr were not changed by administration aspirin-dipyridamole, sudoxicam, or high molecular weight dextran. These studies suggest that membrane are continually lost during circulation vivo, process is unaffected pharmacologic inhibition function.
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