Pyloric gland adenoma arising in Barrett’s esophagus with mucin immunohistochemical and molecular cytogenetic evaluation

摘要: Pyloric gland adenoma is a recently described and very rare entity. The occurrence of unusual in Barrett's epithelium the esophagus. We report case esophageal polyp showing features pyloric adenoma, which was surrounded by so-called specialized columnar epithelium. Immunohistochemically, most tumor glands were strongly positive for MUC6, except superficial layer. MUC5AC almost all cells, but MUC2 CD10 negative tumor. MIB-1-positive proliferating cells distributed throughout Microdissection comparative genomic hybridization analyses revealed losses on 2p24-25.2, 2q14.1-ter, 5q31.3-32, 6q23-24, 8q23-24.2, 11q22.3-24 18q21.1-22. This first found to arise esophagus, its unstable precancerous nature.