An Outbreak of Coronavirus OC43 Respiratory Infection in Normandy, France

作者: Astrid Vabret , Thomas Mourez , Stephanie Gouarin , Joelle Petitjean , Francois Freymuth

DOI: 10.1086/374222

关键词: Common coldHuman coronavirus OC43Respiratory infectionVirologyBronchiolitisInfluenzavirus BRespiratory tract infectionsRhinovirusCoronavirusMedicine

摘要: The 2 groups of human coronaviruses (HCoVs) represented by the prototype strains HCoV 229E and OC43 are mostly known as viruses responsible for common cold syndrome. HCoVs difficult to detect, epidemiological data rare. From October 2000 through April 2001, we tested 1803 respiratory samples reverse-transcriptase polymerase chain reaction. 8 February 27 March was detected in obtained from 30 (6%) 501 patients. other were syncytial virus (6.1%), parainfluenza 3 (1%), influenza A (7.8%), B (7.2%), rhinovirus (6.4%), enterovirus adenovirus (2%). Infection with patients all age groups. following clinical symptoms noted: fever (in 59.8% patients), general 30%), digestive problems 56.8%), rhinitis 36.6%), pharyngitis laryngitis 3.3%), otitis 13.3%), bronchitis 16.6%), bronchiolitis 10%), pneumonia 6.6%). This study shows that an outbreak infection lower tract observed nearly one-third identified active surveillance coronavirus infection.

参考文章(18)
B Lina, M Valette, S Foray, J Luciani, J Stagnara, D M See, M Aymard, Surveillance of community-acquired viral infections due to respiratory viruses in Rhone-Alpes (France) during winter 1994 to 1995. Journal of Clinical Microbiology. ,vol. 34, pp. 3007- 3011 ,(1996) , 10.1128/JCM.34.12.3007-3011.1996
O Moscovici, P Lebon, S Rousset, C Chany, Association of coronavirus infection with neonatal necrotizing enterocolitis. Pediatrics. ,vol. 69, pp. 209- 214 ,(1982)
Astrid Vabret, Franck Mouthon, Thomas Mourez, Stephanie Gouarin, Joëlle Petitjean, François Freymuth, Direct diagnosis of human respiratory coronaviruses 229E and OC43 by the polymerase chain reaction. Journal of Virological Methods. ,vol. 97, pp. 59- 66 ,(2001) , 10.1016/S0166-0934(01)00343-3
François Freymuth, Astrid Vabret, Françoise Galateau-Salle, Janine Ferey, Geneviève Eugene, Joelle Petitjean, Evelyne Gennetay, Jacques Brouard, Mikael Jokik, Jean-François Duhamel, Bernard Guillois, Detection of respiratory syncytial virus, parainfluenzavirus 3, adenovirus and rhinovirus sequences in respiratory tract of infants by polymerase chain reaction and hybridization Clinical and Diagnostic Virology. ,vol. 8, pp. 31- 40 ,(1997) , 10.1016/S0928-0197(97)00060-3
S. Myint, S. Johnston, G. Sanderson, H. Simpson, Evaluation of nested polymerase chain methods for the detection of human coronaviruses 229E and OC43 Molecular and Cellular Probes. ,vol. 8, pp. 357- 364 ,(1994) , 10.1006/MCPR.1994.1052