Synthesis and assessment of a maleimide functionalized BF2 azadipyrromethene near-infrared fluorochrome.
作者： Dan Wu , Shane Cheung , Marc Devocelle , Li-Jun Zhang , Zhi-Long Chen
DOI: 10.1039/C5CC06137G
关键词: Stereochemistry 、 Chemistry 、 In vivo 、 Thiol 、 Glutathione 、 Maleimide 、 Cell-penetrating peptide 、 Fluorescence 、 Azadipyrromethene 、 Conjugate 、 Combinatorial chemistry
摘要: The first water soluble maleimide bearing NIR BF2-azadipyrromethene (NIR-AZA) fluorochrome has been synthesised which is capable of rapid thiol conjugations in with peptides such as glutathione, the cell penetrating peptide (CPP) C(β-A)SKKKKTKV-NH2 and a substituted cRGD. fluorescence imaging showed cellular delivery CPP conjugate effective vivo tumour localization for cRGD conjugate.
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