Biocompatible and Biodegradable Bioplastics Constructed from Chitin via a “Green” Pathway for Bone Repair

作者: Meng He , Xiaolan Wang , Zhenggang Wang , Lingyun Chen , Yao Lu

DOI: 10.1021/ACSSUSCHEMENG.7B02051

关键词: Fourier transform infrared spectroscopyMaterials scienceComposite numberAqueous solutionEnvironmentally friendlyChemical engineeringSelf-healing hydrogelsChitinPolymer chemistryBiocompatibilityBioplastic

摘要: Biodegradable plastics are urgently needed in the biomedical field to avoid secondary surgery for implants after completing repair of nonload bearing bone defects. Herein, novel chitin based were successfully fabricated by changing shape and aggregation state structure hydrogels through drying under a negative pressure, which led plastic deformation. The prepared using an environmentally friendly aqueous NaOH/urea solvent, then radially oriented pressure form bioplastics (CP) on basis removability molecular bundles hydrogels. Moreover, hydroxyapatite (HAP) was situ synthesized obtain chitin/HAP composite (CHP). Their properties characterized SEM, FTIR, 13C NMR, X-ray diffraction mechanical testing. results indicated that bioplastic preparation “green” physical process, incorporation HAP reinforced significantly t...

参考文章(52)
Florent David, Tanya J. Levingstone, Wilfried Schneeweiss, Marie de Swarte, Hanne Jahns, John P. Gleeson, Fergal J. O'Brien, Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a thoroughbred filly. Journal of Tissue Engineering and Regenerative Medicine. ,vol. 9, pp. 1193- 1199 ,(2015) , 10.1002/TERM.2006
Guinea BC Cardoso, Devid Maniglio, Fabio Z Volpato, Abhishek Tondon, Claudio Migliaresi, Roland R Kaunas, Cecilia AC Zavaglia, None, Oleic Acid Surfactant In Polycaprolactone/hydroxyapatite-composites For Bone Tissue Engineering Journal of Biomedical Materials Research Part B. ,vol. 104, pp. 1076- 1082 ,(2016) , 10.1002/JBM.B.33457
Ning Yan, Xi Chen, Sustainability: Don't waste seafood waste Nature. ,vol. 524, pp. 155- 157 ,(2015) , 10.1038/524155A
Mari Kawata, Kazuo Azuma, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku, Biomineralization of calcium phosphate crystals on chitin nanofiber hydrogel for bone regeneration material. Carbohydrate Polymers. ,vol. 136, pp. 964- 969 ,(2016) , 10.1016/J.CARBPOL.2015.10.009
Despina D Deligianni, Nikoleta D Katsala, Petros G Koutsoukos, Yiannis F Missirlis, Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength. Biomaterials. ,vol. 22, pp. 87- 96 ,(2000) , 10.1016/S0142-9612(00)00174-5
Elaine Quinlan, Adolfo López-Noriega, Emmet Thompson, Helena M. Kelly, Sally Ann Cryan, Fergal J. O'Brien, Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering. Journal of Controlled Release. ,vol. 198, pp. 71- 79 ,(2015) , 10.1016/J.JCONREL.2014.11.021
A Anitha, S Sowmya, PT Sudheesh Kumar, S Deepthi, KP Chennazhi, H Ehrlich, M Tsurkan, R Jayakumar, None, Chitin and Chitosan in Selected Biomedical Applications Progress in Polymer Science. ,vol. 39, pp. 1644- 1667 ,(2014) , 10.1016/J.PROGPOLYMSCI.2014.02.008
Sandra Pina, Joaquim M Oliveira, Rui L Reis, None, Natural-Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review Advanced Materials. ,vol. 27, pp. 1143- 1169 ,(2015) , 10.1002/ADMA.201403354
Susmita Bose, Mangal Roy, Amit Bandyopadhyay, Recent advances in bone tissue engineering scaffolds. Trends in Biotechnology. ,vol. 30, pp. 546- 554 ,(2012) , 10.1016/J.TIBTECH.2012.07.005
Bo Duan, Xing Zheng, Zhixiong Xia, Xiaoli Fan, Lin Guo, Jianfeng Liu, Yanfeng Wang, Qifa Ye, Lina Zhang, Highly Biocompatible Nanofibrous Microspheres Self‐Assembled from Chitin in NaOH/Urea Aqueous Solution as Cell Carriers Angewandte Chemie. ,vol. 54, pp. 5152- 5156 ,(2015) , 10.1002/ANIE.201412129