Mitogenic signal transduction pathways in meningiomas: novel targets for meningioma chemotherapy?
作者： Mahlon Johnson , Steven Toms
DOI: 10.1097/01.JNEN.0000189834.63951.81
关键词: Growth factor receptor 、 Phospholipase 、 Apoptosis 、 Signal transduction 、 Cancer research 、 Growth factor 、 Kinase 、 Biology 、 Receptor 、 Meningioma
摘要: The roles of growth factor receptors and numerous downstream regulatory pathways are increasing interest in neuro-oncology. These have been extensively studied gliomas but only recently analyzed meningiomas. This article reviews current research on the receptor-Ras-Raf-1-MEK-1-MAPK, PI3K-Akt/PKB, PLC-gamma1-PKC, phospholipase A2-cyclooxygenase, TGF-beta receptor-Smad that appear to regulate meningioma inhibit apoptosis. Sites along these receptor/kinase cascades might be targeted by novel therapies also discussed.
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