RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice.
作者： Sang-Soo Kim , Dan Peer , Priti Kumar , Sandesh Subramanya , Huaquan Wu
DOI: 10.1038/MT.2009.271
关键词: Viral pathogenesis 、 Lymphocyte function-associated antigen 1 、 Gene silencing 、 Gene knockdown 、 Small interfering RNA 、 Humanized mouse 、 Biology 、 Virology 、 In vivo 、 RNA interference
摘要: … (b) The CCR5 levels in peripheral blood CD14 + monocytes were measured by RT-PCR before, and 3 and 10 days after siRNA treatment from blood collected. Reduction in CCR5 …
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