Extracts of Cerbera manghas L. effectively inhibit the viability of glioblastoma cell lines and their cancer stemloids in vitro and in mouse xenograft model
作者： Jui-Cheng Tsai , Wen-Shan Liu , Ying-Ting Tseng , Hoi-Ian Lam , Szu-Ying Chen
DOI: 10.1016/J.JFF.2018.07.017
关键词: Cell cycle 、 Cerbera manghas 、 Apoptosis 、 Stem cell marker 、 Cancer research 、 Chemistry 、 Stem cell 、 Cell culture 、 Glioma 、 Cancer stem cell
摘要: Abstract Glioblastoma multiforme (GBM), a highly recurrent malignant disease, is grade IV glioma with poor prognosis. stem cells (GSCs) are the new potential target for GBM intervention. To develop an improved treatment by targeting GSCs, we identified neriifolin, active principle in extracts of Cerbera manghas L., as effective inhibitor growth and migration cell lines their tumorspheres. In this study, neriifolin effectively inhibited colony formation CD133+ Both C. Akt activation caused cycle G1 arrest. They also reduced expression marker Sox2. Treatment higher doses induced apoptosis Furthermore, tumorsphere-derived tumors vivo. summary, obtained from may serve drug lead compound therapies.
sci-hub.se 参考文章(50)
Trân Thi Minh Hiên, Ch. Navarro-Delmasure, Trân Vy, Toxicity and effects on the central nervous system of a Cerbera odollam leaf extract. Journal of Ethnopharmacology. ,vol. 34, pp. 201- 206 ,(1991) , 10.1016/0378-8741(91)90038-F
David Kassop, Michael S. Donovan, Brian M. Cohee, Donovan L. Mabe, Erich F. Wedam, John E. Atwood, An unusual case of cardiac glycoside toxicity International Journal of Cardiology. ,vol. 170, pp. 434- 437 ,(2014) , 10.1016/J.IJCARD.2013.11.019
Yaping Sun, Zhiqiang Dong, Hadie Khodabakhsh, Sandip Chatterjee, Su Guo, Zebrafish Chemical Screening Reveals the Impairment of Dopaminergic Neuronal Survival by Cardiac Glycosides PLoS ONE. ,vol. 7, pp. e35645- ,(2012) , 10.1371/JOURNAL.PONE.0035645
Peng Wei, Chen Zhiyu, Tang Xu, Zheng Xiangwei, Antitumor effect and apoptosis induction of Alocasia cucullata (Lour.) G. Don in human gastric cancer cells in vitro and in vivo. BMC Complementary and Alternative Medicine. ,vol. 15, pp. 33- 33 ,(2015) , 10.1186/S12906-015-0554-2
Shideng Bao, Qiulian Wu, Roger E. McLendon, Yueling Hao, Qing Shi, Anita B. Hjelmeland, Mark W. Dewhirst, Darell D. Bigner, Jeremy N. Rich, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature. ,vol. 444, pp. 756- 760 ,(2006) , 10.1038/NATURE05236
Guo-Fei Wang, Yue-Wei Guo, Bo Feng, Liang Li, Cai-Guo Huang, Bing-Hua Jiao, Tanghinigenin from seeds of Cerbera manghas L. induces apoptosis in human promyelocytic leukemia HL-60 cells. Environmental Toxicology and Pharmacology. ,vol. 30, pp. 31- 36 ,(2010) , 10.1016/J.ETAP.2010.03.012
Bo Feng, Yue-Wei Guo, Cai-Guo Huang, Liang Li, Bing-Hua Jiao, None, β-d-Glucosyl-(1–4)-α-l-thevetosides of 17β-digitoxigenin from seeds of Cerbera manghas L. induces apoptosis in human hepatocellular carcinoma HepG2 cells Experimental and Toxicologic Pathology. ,vol. 64, pp. 403- 410 ,(2012) , 10.1016/J.ETP.2010.10.005
Surat Laphookhieo, Sarot Cheenpracha, Chatchanok Karalai, Suchada Chantrapromma, Yanisa Rat-a-pa, Chanita Ponglimanont, Kan Chantrapromma, Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam. Phytochemistry. ,vol. 65, pp. 507- 510 ,(2004) , 10.1016/J.PHYTOCHEM.2003.10.019
Michelle R. Embry, Scott E. Belanger, Thomas A. Braunbeck, Malyka Galay-Burgos, Marlies Halder, David E. Hinton, Marc A. Léonard, Adam Lillicrap, Teresa Norberg-King, Graham Whale, The fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research. Aquatic Toxicology. ,vol. 97, pp. 79- 87 ,(2010) , 10.1016/J.AQUATOX.2009.12.008
Bo Feng, Cai-Guo Huang, Ruo-Hua Chen, Yue-Wei Guo, Bing-Hua Jiao, 2 '-Epi-2 '-O-acetylthevetin B induces apoptosis partly via Ca2+-mediated mitochondrial pathway in human hepatocellular carcinoma HepG2 cells Cell Biology International. ,vol. 33, pp. 918- 925 ,(2009) , 10.1016/J.CELLBI.2009.06.013