Long-term outcome of mothers of children with complete congenital heart block

摘要: Objectives To determine the health of mothers offspring with complete congenital heart block (CHB) both at time delivery affected child and in long-term, percentage children CHB who had antiSSA/Ro and/or SSB/La antibodies. Patients methods Sixty-four 64 (seen between 1964 1993) were identified through Cardiology database The Hospital for Sick Children, Toronto, Canada. Medical information from these was evaluated. Data obtained by mailed questionnaire, telephone interview, attending physicians. presence anti-Ro antibodies anti-La evaluated ELISA assay. Results mean age first 28 ± 6 years. At 42 (66%) healthy, 2 (3%) systemic lupus erythematosus (SLE), linear scleroderma, rheumatoid arthritis; 3 (5%) a history rheumatic fever (but otherwise well), 1 (2%) Sjogren's syndrome (SS), 12 (19%) an undifferentiated autoimmune (UAS) (arthralgia, myalgia, photosensitivity, skin vasculitis, Raynaud's phenomenon). to follow-up study 121 88 months. maternal 38 9 Three initially UAS progressed SLE (average 80 months, median 96), developed SS (with average 140 132) went into remission. other did not develop disease 150 102 Thirty-six healthy remained well. One mother SLE; hyperthyroidism; ankylosing spondylitis; UAS. 36 similar (123 97 months) (121 months). Anti-Ro positive 32 53 (60%) tested. Fourteen symptomatic 39 asymptomatic. 13 tested delivery. Conclusions long-term outcome our cohort very good as most well follow-up. Twenty-five percent only 2% SLE. development asymptomatic birth less common than previous studies. However, close is warranted.