Optimising antimicrobial drug use in surgery: an intervention study in a Dutch university hospital

摘要: Following a one-month prospective study of antimicrobial drug use in surgical departments, new guidelines were implemented. The review was repeated after two years. In both periods, one third patients prescribed drugs. Prophylactic antibiotic consumption decreased from 0.75 to 0.53 defined daily doses/operation. Compliance with improved 32% 79%. Duration prophylaxis > 24 h 21 % 8%. Single dose increased 34% 80%. Quality the prophylactic courses improved, as evaluated by experts using established criteria. For prophylaxis, cost savings amounted 57%. Better quality therapeutic associated increase 15%. Indicators satisfactory outcome policy stable median length stay (5.5 days first and 5.0 intervention) reduction number nosocomial infections treated drugs/100 bed (1.0 before intervention vs 0.77 intervention).