Unraveling the novel anti-osteosarcoma function of coptisine and its mechanisms.

摘要: Uncontrolled cell proliferation and robust angiogenesis play critical roles in osteosarcoma growth metastasis. In this study we explored novel agents derived from traditional Chinese medicinal herbs that potently inhibit Coptisine, an active component of the herb Coptidis rhizoma, markedly inhibited aggressive proliferation. Coptisine induced cycle arrest at G0/G1 phase through downregulation CDK4 cyclin D1 expression effectively suppressed tumor a xenografted mouse model. significantly impeded migration, invasion, capillary-like network formation by decreasing VE-cadherin integrin s3, diminishing STAT3 phosphorylation. elevated blood erythrocyte hemoglobin levels while still remaining within normal range. It also moderately increased white platelet counts. These data suggest coptisine exerts strong anti-osteosarcoma effect with very low toxicity is potential drug candidate.