RcoA has pleiotropic effects on Aspergillus nidulans cellular development.
作者： Julie Hicks , Robin A. Lockington , Joseph Strauss , Daniel Dieringer , Christian P. Kubicek
DOI: 10.1046/J.1365-2958.2001.02332.X
关键词: Repressor 、 Catabolite repression 、 Genetics 、 Biology 、 Fungal protein 、 Protein family 、 Aspergillus nidulans 、 Neurospora crassa 、 Regulator gene 、 Saccharomyces cerevisiae
摘要: Aspergillus nidulans rcoA encodes a member of the WD repeat family proteins. The RcoA protein shares sequence similarity with other members this family, including Saccharomyces cerevisiae Tup1p and Neurospora crassa RCO1. is involved in negative regulation an array functions carbon catabolite repression. RCO1 regulating pleiotropic developmental processes, but not In A. nidulans, deletion (DeltarcoA), recessive mutation, resulted gross defects vegetative growth, asexual spore production sterigmatocystin (ST) biosynthesis. Expression ST pathway-specific regulatory genes, brlA aflR, respectively, signal transduction genes (i.e. flbA, fluG or fadA) aflR expression was delayed (brlA) eliminated (aflR) DeltarcoA strain. Overexpression strain could rescue normal downstream targets AflR. CreA-dependent repression starch ethanol utilization only weakly affected strong role development, growth production, compared relatively weak repression, similar to N. crassa.
core.ac.uk
sci-hub.se 参考文章(49)
G. Pontecorvo, J.A. Roper, L.M. Chemmons, K.D. Macdonald, A.W.J. Bufton, The Genetics of Aspergillus nidulans Advances in Genetics. ,vol. 5, pp. 141- 238 ,(1953) , 10.1016/S0065-2660(08)60408-3
Etta Käfer, Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations. Advances in Genetics. ,vol. 19, pp. 33- 131 ,(1977) , 10.1016/S0065-2660(08)60245-X
J.O. Nehlin, M. Carlberg, H. Ronne, Control of yeast GAL genes by MIG1 repressor: a transcriptional cascade in the glucose response. The EMBO Journal. ,vol. 10, pp. 3373- 3377 ,(1991) , 10.1002/J.1460-2075.1991.TB04901.X
J. H. Yu, J. Wieser, T. H. Adams, The Aspergillus FlbA RGS domain protein antagonizes G protein signaling to block proliferation and allow development The EMBO Journal. ,vol. 15, pp. 5184- 5190 ,(1996) , 10.1002/J.1460-2075.1996.TB00903.X
Y Mukai, S Harashima, Y Oshima, AAR1/TUP1 protein, with a structure similar to that of the beta subunit of G proteins, is required for a1-alpha 2 and alpha 2 repression in cell type control of Saccharomyces cerevisiae. Molecular and Cellular Biology. ,vol. 11, pp. 3773- 3779 ,(1991) , 10.1128/MCB.11.7.3773
Kiminori Shimizu, Nancy P. Keller, Genetic Involvement of a cAMP-Dependent Protein Kinase in a G Protein Signaling Pathway Regulating Morphological and Chemical Transitions in Aspergillus nidulans Genetics. ,vol. 157, pp. 591- 600 ,(2001) , 10.1093/GENETICS/157.2.591
Thomas H. Adams, Robert A. E. Butchko, Nancy P. Keller, Aspergillus nidulans mutants defective in stc gene cluster regulation. Genetics. ,vol. 153, pp. 715- 720 ,(1999) , 10.1093/GENETICS/153.2.715
Seth Fidel, John H. Doonan, N.Ronald Morris, Aspergillus nidulans contains a single actin gene which has unique intron locations and encodes a γ-actin Gene. ,vol. 70, pp. 283- 293 ,(1988) , 10.1016/0378-1119(88)90200-4
Joan M. Kelly, M. J. Hynes, Increased and decreased sensitivity to carbon catabolite repression of enzymes of acetate metabolism in mutants of Aspergillus nidulans. Molecular Genetics and Genomics. ,vol. 156, pp. 87- 92 ,(1977) , 10.1007/BF00272256
Eva J. Neer, Carl J. Schmidt, Raman Nambudripad, Temple F. Smith, The ancient regulatory-protein family of WD-repeat proteins Nature. ,vol. 371, pp. 297- 300 ,(1994) , 10.1038/371297A0