Glucose “peak” and glucose “spike”: Impact on endothelial function and oxidative stress

摘要: Abstract Aim Data suggest that 2h hyperglycaemia during an OGTT is less predictive for cardiovascular disease of the glucose "spike" (the difference between baseline level and "peak" test). Methods A euinsulinemic hyperglycaemic clamp at 10 15mmol/l glucose, with or without vitamin C, was given in increasing steps diabetic normal subjects. Moreover, a clamp, 10mmol/l, performed two groups patients different levels fasting glycaemia. In both experiments flow mediated dilation nitrotyrosine were measured. Results Glucose resulted concentration-dependent induction endothelial dysfunction oxidative stress. Vitamin C counterbalanced this effect. The increase glycaemia to 10mmol/l induced significant increased diabetics However, when delta basal value peak value) function evaluated, lower values showed worse outcome. Conclusions Our data same grading almost super imposable, but clearly terms from