Genetics of inflammatory bowel disease.

作者: Richard H. Duerr

DOI: 10.1002/IBD.3780020108

关键词: Human leukocyte antigenImmunologyDiseaseAutoantibodyBiologyCrohn's diseaseFamily aggregationConcordanceGeneticsUlcerative colitisInflammatory bowel disease

摘要: Summary:Genetic influence in the susceptibility to inflammatory bowel disease (IBD) is suggested by racial, ethnic, and familial aggregation of disease. Increased concordance for IBD monozygotic compared with dizygotic twins suggests that genetic rather than environmental factors are primarily re

参考文章(158)
A. Van Gossum, J. F. Colombel, E. Dupont, J. C. Paris, F. Guillemot, F. Dufosse, A. Cortot, Familial Crohn's disease in multiple siblings: no linkage to the HLA system. Gastroenterologie Clinique Et Biologique. ,vol. 13, pp. 676- 678 ,(1989)
Herbert L. DuPont, Charles D. Ericsson, John J. Mathewson, Salma Marani, Anne-Laure Knellwolf-Cousin, Francisco G. Martinez-Sandoval, Zaldaride maleate, an intestinal calmodulin inhibitor, in the therapy of travelers' diarrhea Gastroenterology. ,vol. 104, pp. 709- 715 ,(1993) , 10.1016/0016-5085(93)91005-3
Grossman A, Theodor E, Lilos P, Eshchar Y, Fireman Z, Gilat T, Epidemiology of Crohn's disease in the Jewish population of central Israel, 1970-1980. The American Journal of Gastroenterology. ,vol. 84, pp. 255- ,(1989)
I Segal, A R Walker, D G Hamilton, L O Tim, The rarity of ulcerative colitis in South African blacks. The American Journal of Gastroenterology. ,vol. 74, pp. 332- 336 ,(1980)
Daniel K. Podolsky, Kurt J. Isselbacher, Glycoprotein Composition of Colonic Mucosa Gastroenterology. ,vol. 87, pp. 991- 998 ,(1984) , 10.1016/S0016-5085(84)80055-4
Kim L. Isaacs, R.Balfour Sartor, Stephen Haskill, Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification. Gastroenterology. ,vol. 103, pp. 1587- 1595 ,(1992) , 10.1016/0016-5085(92)91182-4
R. Lagercrantz, P. Perlmann, S. Hammarström, Immunological Studies in Ulcerative Colitis: V. Family studies Gastroenterology. ,vol. 60, pp. 381- 389 ,(1971) , 10.1016/S0016-5085(71)80117-8
J A Williamson, D T Bishop, The power of identity-by-state methods for linkage analysis. American Journal of Human Genetics. ,vol. 46, pp. 254- 265 ,(1990)
Amnon Sonnenberg, Irene H. Wasserman, Epidemiology of inflammatory bowel disease among U.S. Military veterans Gastroenterology. ,vol. 101, pp. 122- 130 ,(1991) , 10.1016/0016-5085(91)90468-Z