Anti-FLT3 antibodies
作者： Ludger Grosse-Hovest , Hans-Joerg Buehring , Grundram Jung , Martin Hofmann , Steffen Aulwurm
DOI:
关键词: Amino acid 、 Biology 、 Fragment crystallizable region 、 Molecular biology 、 Cell cytotoxicity 、 Biochemistry 、 Antibody 、 Antibody-dependent cell-mediated cytotoxicity 、 Nucleic acid
摘要: The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitutions 239D and 332E enhance antibody-dependent cell cytotoxicity (ADCC) of these antibodies. further pharmaceutical compositions containing antibodies, nucleic acids encoding as well methods using such
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