Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway.

作者: Yuan Yuan , Xue Xue , Ruo‐Bing Guo , Xiu‐Lan Sun , Gang Hu

DOI: 10.1111/J.1755-5949.2012.00319.X

关键词: Astrocyte differentiationTemozolomidePI3K/AKT/mTOR pathwayProtein kinase AAMPKProliferation indexResveratrolBiologyPharmacologySignal transduction

摘要: … We found that TMZ plus resveratrol could significantly … ROS-induced AMPK activation was involved in the mechanism of additive antitumor effects of combination of TMZ and resveratrol …

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