O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas
作者： C-H Fan , W-L Liu , H Cao , C Wen , L Chen
关键词:
摘要: … Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-… Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA …
nature.com
sci-hub.se 参考文章(77)
Mohamed Elhamri, Xavier Thomas, Tipifarnib in the treatment of acute myeloid leukemia. Biologics: Targets & Therapy. ,vol. 1, pp. 415- 424 ,(2007)
Emmanuèle Lechapt-Zalcman, Guénaëlle Levallet, Audrey Emmanuelle Dugué, Anne Vital, Marie-Danièle Diebold, Philippe Menei, Philippe Colin, Philippe Peruzzy, Evelyne Emery, Myriam Bernaudin, Françoise Chapon, Jean-Sébastien Guillamo, O6‐methylguanine‐DNA methyltransferase (MGMT) promoter methylation and low MGMT‐encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery followed by radiotherapy with concomitant and adjuvant temozolomide Cancer. ,vol. 118, pp. 4545- 4554 ,(2012) , 10.1002/CNCR.27441
Yuan Yuan, Xue Xue, Ruo‐Bing Guo, Xiu‐Lan Sun, Gang Hu, Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway. CNS Neuroscience & Therapeutics. ,vol. 18, pp. 536- 546 ,(2012) , 10.1111/J.1755-5949.2012.00319.X
Bart Neyns, Alicia Tosoni, Wen-Jen Hwu, David A. Reardon, Dose-dense temozolomide regimens: antitumor activity, toxicity, and immunomodulatory effects. Cancer. ,vol. 116, pp. 2868- 2877 ,(2010) , 10.1002/CNCR.25035
Shanbao Cai, Yi Xu, Ryan J. Cooper, Michael J. Ferkowicz, Jennifer R. Hartwell, Karen E. Pollok, Mark R. Kelley, Mitochondrial Targeting of Human O6-Methylguanine DNA Methyltransferase Protects against Cell Killing by Chemotherapeutic Alkylating Agents Cancer Research. ,vol. 65, pp. 3319- 3327 ,(2005) , 10.1158/0008-5472.CAN-04-3335
Maria Grazia Ferlin, Gianfranco Chiarelotto, Venusia Gasparotto, Lisa Dalla Via, Vincenzo Pezzi, Luisa Barzon, Giorgio Palù, Ignazio Castagliuolo, Synthesis and in vitro and in vivo antitumor activity of 2-phenylpyrroloquinolin-4-ones. Journal of Medicinal Chemistry. ,vol. 48, pp. 3417- 3427 ,(2005) , 10.1021/JM049387X
Matthew D Weitzman, Christian T Carson, Rachel A Schwartz, Caroline E Lilley, Interactions of viruses with the cellular DNA repair machinery. DNA Repair. ,vol. 3, pp. 1165- 1173 ,(2004) , 10.1016/J.DNAREP.2004.03.018
LIYONG HUANG, YE XU, GUOXIANG CAI, ZUQING GUAN, SANJUN CAI, Downregulation of S100A4 expression by RNA interference suppresses cell growth and invasion in human colorectal cancer cells Oncology Reports. ,vol. 27, pp. 917- 922 ,(2012) , 10.3892/OR.2011.1598
Bernd Kaina, Markus Christmann, Steffen Naumann, Wynand P. Roos, MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair. ,vol. 6, pp. 1079- 1099 ,(2007) , 10.1016/J.DNAREP.2007.03.008
Markus Christmann, Georg Nagel, Sigrid Horn, Ulrike Krahn, Dorothee Wiewrodt, Clemens Sommer, Bernd Kaina, MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma. International Journal of Cancer. ,vol. 127, pp. 2106- 2118 ,(2010) , 10.1002/IJC.25229