IgG4- related disease as a rare cause of tubulointerstitial nephritis.

摘要: Isolated IgG4 tubulointerstitial nephritis (TIN) is a rare disorder characterized by raised serum levels and histological findings of dense lymphoplasmacytic infiltrates rich in positive plasma cells. We report case isolated TIN that presented with acute kidney injury an 84 year old man polyclonal increase his total IgG IgE 381 kUA/L but without evidence systemic autoimmunity. draw parallel IgG4-related autoimmune pancreatitis show circulating regulatory T Importantly the cell cytokine, IL10, TH1 cytokines IL12 IFNγ, proinflammatory TNF α immune IL27 were all highly raised. Furthermore, level IL21 promotes production was also very significantly elevated. These results suggest efforts system to reduce inflammation suppress exaggerated Th2 response. A setting absence autoimmunity chronic infection should encourage assessment subclasses. Prompt steroid treatment those may ongoing renal damage.