Amount of CD4+CD25+ regulatory T cells in autoimmune pancreatitis and pilonidal sinus.
作者： Yuki Fukumura , Masaru Takase , Keiko Mitani , Koichi Suda , Abdukadir Imamhasan
DOI: 10.1097/MPA.0B013E31823E3C66
关键词:
摘要: OBJECTIVES Infiltration of many IgG4-positive plasma cells (G4-Ps) is seen in IgG4-related diseases and several "non-IgG4-related diseases," such as pilonidal sinus (PS) well. The involvement CD4+CD25+ regulatory T (CD4CD25 Tregs) has been reported. To see whether Tregs are involved autoimmune pancreatitis (AIP)/non-IgG4-related with G4-Ps, we investigated the amount G4-Ps histologically AIP/PS. METHODS Four AIP 10 PS were immunostained IgG4/Foxp3, a specific marker for Tregs. Double immunohistochemistry dual fluorescent conducted to RESULTS All 30% showed abundant G4-Ps. infiltrated diffusely all AIPs patchy pattern at abscess/granulation foci. Foxp3 immunostaining/double moderate abscess PS, but few granulation PS. Dual also AIP. CONCLUSIONS Many lesions, not suggesting that sometimes do synchronize might relate inflammatory activity both
sci-hub.se 参考文章(11)
Orra N. Davage, The origin of sacrococcygeal pilonidal sinuses based on an analysis of four hundred sixty-three cases. American Journal of Pathology. ,vol. 30, pp. 1191- 1205 ,(1954)
Hideaki Hamano, Shigeyuki Kawa, Akira Horiuchi, Hiroshi Unno, Naoyuki Furuya, Taiji Akamatsu, Mana Fukushima, Toshio Nikaido, Kohzo Nakayama, Nobuteru Usuda, Kendo Kiyosawa, High serum IgG4 concentrations in patients with sclerosing pancreatitis. The New England Journal of Medicine. ,vol. 344, pp. 732- 738 ,(2001) , 10.1056/NEJM200103083441005
Yoh Zen, Takahiko Fujii, Kenichi Harada, Mitsuhiro Kawano, Kazunori Yamada, Masayuki Takahira, Yasuni Nakanuma, Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis. Hepatology. ,vol. 45, pp. 1538- 1546 ,(2007) , 10.1002/HEP.21697
Shohei Hori, Takashi Nomura, Shimon Sakaguchi, Control of Regulatory T Cell Development by the Transcription Factor Foxp3 Science. ,vol. 299, pp. 1057- 1061 ,(2003) , 10.1126/SCIENCE.1079490
Johan Verhagen, Kurt Blaser, Cezmi A. Akdis, Mübeccel Akdis, Mechanisms of allergen-specific immunotherapy: T-regulatory cells and more. Immunology and Allergy Clinics of North America. ,vol. 26, pp. 207- 231 ,(2006) , 10.1016/J.IAC.2006.02.008
Kenji Hirano, Takao Kawabe, Natsuyo Yamamoto, Yousuke Nakai, Naoki Sasahira, Takeshi Tsujino, Nobuo Toda, Hiroyuki Isayama, Minoru Tada, Masao Omata, Serum IgG4 concentrations in pancreatic and biliary diseases. Clinica Chimica Acta. ,vol. 367, pp. 181- 184 ,(2006) , 10.1016/J.CCA.2005.11.031
Kazuichi Okazaki, Hideaki Miyoshi, Kazushige Uchida, Takao Taniguchi, Shujiro Yazumi, Mitsunobu Matsushita, Makoto Takaoka, Circulating naïve and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis. Pancreas. ,vol. 36, pp. 133- 140 ,(2008) , 10.1097/MPA.0B013E3181577553
Kenji Notohara, Lawrence J. Burgart, Dhiraj Yadav, Suresh Chari, Thomas C. Smyrk, Idiopathic chronic pancreatitis with periductal lymphoplasmacytic infiltration: clinicopathologic features of 35 cases The American Journal of Surgical Pathology. ,vol. 27, pp. 1119- 1127 ,(2003) , 10.1097/00000478-200308000-00009
Giuseppe Zamboni, Jutta L�ttges, Paola Capelli, Luca Frulloni, Giorgio Cavallini, Paolo Pederzoli, Alexander Leins, Daniel Longnecker, G�nter Kl�ppel, Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens Virchows Archiv. ,vol. 445, pp. 552- 563 ,(2004) , 10.1007/S00428-004-1140-Z
Haruhiko Yagi, Takashi Nomura, Kyoko Nakamura, Sayuri Yamazaki, Toshio Kitawaki, Shohei Hori, Michiyuki Maeda, Masafumi Onodera, Takashi Uchiyama, Shingo Fujii, Shimon Sakaguchi, Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells International Immunology. ,vol. 16, pp. 1643- 1656 ,(2004) , 10.1093/INTIMM/DXH165