3D-printed biodegradable gyroid scaffolds for tissue engineering applications
作者： Loïc Germain , Carlos A. Fuentes , Aart W. van Vuure , Anne des Rieux , Christine Dupont-Gillain
DOI: 10.1016/J.MATDES.2018.04.037
关键词: Composite material 、 Materials science 、 Crystallinity 、 Scaffold 、 Porosity 、 Gyroid 、 Tissue engineering 、 3d printed 、 Fused deposition modeling
摘要: Abstract Fused deposition modeling (FDM), a low-cost and easy-to-use additive manufacturing technique, was used to produce poly(lactic acid) (PLA) gyroid scaffolds. Such morphology selected for its spring shape, high porosity leading good nutrient waste diffusion, favorable mechanical properties. Printing parameters were optimized the need of support material improve printing evidenced. The compared common strut-based structure. Scaffold measured by micro-CT, properties determined compression tests, taking into account effect geometry, resolution, PLA crystallinity. impact scaffold geometry crystallinity on degradation studied in vitro. Porosity structure 71%, as expected from model. tests showed an isotropic behavior gyroid, contrast with scaffold. Upon aging physiological conditions, scaffolds retained their integrity during 64 weeks, while control lost struts starting week 33, way that depended resolution. Based these results, design is proposed suitable mesh architecture tissue engineering can be elaborated using FDM techniques, personalized implants.
sci-hub.se 参考文章(50)
Vincenzo Guarino, Marica Marrese, Luigi Ambrosio, Chemical and Physical Properties of Polymers for Biomedical Use Advanced Polymers in Medicine. pp. 67- 90 ,(2015) , 10.1007/978-3-319-12478-0_3
Linjun Tang, Xiaocheng Lu, Ronglan Zhu, Tengda Qian, Yi Tao, Kai Li, Jinyu Zheng, Penglai Zhao, Shuai Li, Xi Wang, Lixin Li, Adipose-Derived Stem Cells Expressing the Neurogenin-2 Promote Functional Recovery After Spinal Cord Injury in Rat Cellular and Molecular Neurobiology. ,vol. 36, pp. 657- 667 ,(2016) , 10.1007/S10571-015-0246-Y
Falguni Pati, Dong-Heon Ha, Jinah Jang, Hyun Ho Han, Jong-Won Rhie, Dong-Woo Cho, Biomimetic 3D tissue printing for soft tissue regeneration. Biomaterials. ,vol. 62, pp. 164- 175 ,(2015) , 10.1016/J.BIOMATERIALS.2015.05.043
Joshua P Temple, Daphne L Hutton, Ben P Hung, Pinar Yilgor Huri, Colin A Cook, Renu Kondragunta, Xiaofeng Jia, Warren L Grayson, None, Engineering anatomically shaped vascularized bone grafts with hASCs and 3D‐printed PCL scaffolds Journal of Biomedical Materials Research Part A. ,vol. 102, pp. 4317- 4325 ,(2014) , 10.1002/JBM.A.35107
Isaac A Janson, Andrew J Putnam, None, Extracellular matrix elasticity and topography: Material‐based cues that affect cell function via conserved mechanisms Journal of Biomedical Materials Research Part A. ,vol. 103, pp. 1246- 1258 ,(2015) , 10.1002/JBM.A.35254
James A. Dolan, Bodo D. Wilts, Silvia Vignolini, Jeremy J. Baumberg, Ullrich Steiner, Timothy D. Wilkinson, Optical Properties of Gyroid Structured Materials: From Photonic Crystals to Metamaterials Advanced Optical Materials. ,vol. 3, pp. 12- 32 ,(2015) , 10.1002/ADOM.201400333
Sophie C. Cox, John A. Thornby, Gregory J. Gibbons, Mark A. Williams, Kajal K. Mallick, 3D printing of porous hydroxyapatite scaffolds intended for use in bone tissue engineering applications Materials Science and Engineering: C. ,vol. 47, pp. 237- 247 ,(2015) , 10.1016/J.MSEC.2014.11.024
Chunze Yan, Liang Hao, Ahmed Hussein, David Raymont, Evaluations of cellular lattice structures manufactured using selective laser melting International Journal of Machine Tools & Manufacture. ,vol. 62, pp. 32- 38 ,(2012) , 10.1016/J.IJMACHTOOLS.2012.06.002
Maria Ann Woodruff, Dietmar Werner Hutmacher, The return of a forgotten polymer—Polycaprolactone in the 21st century Progress in Polymer Science. ,vol. 35, pp. 1217- 1256 ,(2010) , 10.1016/J.PROGPOLYMSCI.2010.04.002
Hajar Seyednejad, Debby Gawlitta, Raoul V. Kuiper, Alain de Bruin, Cornelus F. van Nostrum, Tina Vermonden, Wouter J.A. Dhert, Wim E. Hennink, In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(ε-caprolactone). Biomaterials. ,vol. 33, pp. 4309- 4318 ,(2012) , 10.1016/J.BIOMATERIALS.2012.03.002