Modulation of pH by neuronal activity

摘要: Although the requirement for a strict regulation of pH in brain is frequently emphasized, recent studies indicate that neuronal activity gives rise to significant changes intracellular and extracellular pH. Given sensitivity many ion channels hydrogen ions, this modulation local might influence function, particularly where shifts are sufficiently large rapid. Studies using pH-sensitive microelectrodes have demonstrated marked cellular regional variability activity-dependent shifts, begun uncover several their underlying mechanisms. Accumulating evidence suggests subcellular dynamics governed by respective localization glial cells, ligand-gated channels, carbonic anhydrase.