Epileptiform activity induced by alkalosis in rat neocortical slices: Block by antagonists of N-methyl-d-aspartate
作者： Julia A. Aram , David Lodge
DOI: 10.1016/0304-3940(87)90112-1
关键词:
摘要: Abstract The effects of changing extracellular pH on epileptiform activity induced by the removal magnesium ions from perfusing medium were studied. proportion bicarbonate in artificial cerebrospinal fluid and CO 2 gas mixture altered to mimic metabolic respiratory acid base disturbances. Changes 0.2 unit control produced marked effects. Epileptiform was enhanced alkalosis diminished acidosis. In normal magnesium-containing (pH > 7.8) spontaneous that blocked selective N- methyl- d -aspartate antagonists. relevance these findings acid/base changes clinical epilepsy is discussed.
sci-hub.se 参考文章(16)
Alain Trautmann, Jacques Neyton, Physiological Modulation of Gap Junction Permeability The Journal of Experimental Biology. ,vol. 124, pp. 93- 114 ,(1986) , 10.1242/JEB.124.1.93
Bo K. Siesjö, Roger von Hanwehr, Görel Nergelius, Gunilla Nevander, Martin Ingvar, Extra- and intracellular pH in the brain during seizures and in the recovery period following the arrest of seizure activity Journal of Cerebral Blood Flow and Metabolism. ,vol. 5, pp. 47- 57 ,(1985) , 10.1038/JCBFM.1985.7
George G. Somjen, Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression. Brain Research. ,vol. 311, pp. 186- 188 ,(1984) , 10.1016/0006-8993(84)91416-1
H. CASPERS, E.-J. SPECKMANN, Cerebral pO 2 , pCO 2 and pH: changes during convulsive activity and their significance for spontaneous arrest of seizures. Epilepsia. ,vol. 13, pp. 699- 725 ,(1972) , 10.1111/J.1528-1157.1972.TB04403.X
M. Gutnick, D. Prince, Dye coupling and possible electrotonic coupling in the guinea pig neocortical slice Science. ,vol. 211, pp. 67- 70 ,(1981) , 10.1126/SCIENCE.7444449
Mark L. Mayer, Gary L. Westbrook, The physiology of excitatory amino acids in the vertebrate central nervous system Progress in Neurobiology. ,vol. 28, pp. 197- 276 ,(1987) , 10.1016/0301-0082(87)90011-6
J. Folbergrová, K. Norberg, B. Quistorff, B. K. Siesjö, CARBOHYDRATE AND AMINO ACID METABOLISM IN RAT CEREBRAL CORTEX IN MODERATE AND EXTREME HYPERCAPNIA Journal of Neurochemistry. ,vol. 25, pp. 457- 462 ,(1975) , 10.1111/J.1471-4159.1975.TB04350.X
H. Walther, J.D.C. Lambert, R.S.G. Jones, U. Heinemann, B. Hamon, Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium Neuroscience Letters. ,vol. 69, pp. 156- 161 ,(1986) , 10.1016/0304-3940(86)90595-1
Bertil Hille, Charges and Potentials at the Nerve Surface : Divalent ions and pH The Journal of General Physiology. ,vol. 51, pp. 221- 236 ,(1968) , 10.1085/JGP.51.2.221
H. Schaer, Decrease in ionized calcium by bicarbonate in physiological solutions. Pflügers Archiv: European Journal of Physiology. ,vol. 347, pp. 249- 254 ,(1974) , 10.1007/BF00592601