Small scale design of experiment investigation of equilibrium solubility in simulated fasted and fed intestinal fluid
作者： Stephanie McPherson , Jeremy Perrier , Claire Dunn , Ibrahim Khadra , Scott Davidson
DOI: 10.1016/J.EJPB.2020.01.016
关键词: Solubility 、 Monoglyceride 、 Physiologically based pharmacokinetic modelling 、 Ibuprofen 、 Intestinal fluid 、 Lecithin 、 Sodium 、 Sodium oleate 、 Chromatography 、 Chemistry 、 Biotechnology 、 Pharmaceutical Science 、 General Medicine
摘要: … The current industrial standard for SIF in solubility studies is either fasted simulated intestinal fluid (FaSSIF) or fed simulated intestinal fluid (FeSSIF) [9] and as such they have been …
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