The Preparation of Substituted Hydroxyphenyl-pyridyl-ethanols and α-Hydroxyphenyl-α-methylpyridineethanols by the Condensation of 2-, 3-, or 4-Picolyllithium with Select Hydroxy-benzaldehydes and 4-Hydroxyacetophenone
作者： Madlene U. Koller , Katrina L. Peariso , Tina S. Guion , Shannon Studer Martinez , Charles F. Beam
DOI: 10.1080/00397919508011427
关键词: Chemistry 、 Dehydration 、 Lithium 、 Medicinal chemistry 、 Condensation 、 Organic chemistry
摘要: Abstract 2-, 3-, or 4-Picolyllithium was prepared in excess lithium diiso-propylamide and condensed with several hydroxy-benzaldehydes 4-hydroxy-acetophenone to afford substituted hydroxyphenyl-pyridyl-ethanols α-hydroxyphenyl-α-methylpyridineethanols. In two instances. 3-picolyllithium aldehydes presumably form the hydroxyphenyl-pyridyl-ethanol, which underwent linear dehydration pyridyl-ethylenyl-phenol.
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