In vitro production of pregnancy-associated plasma protein-A (PAPP-A) by trophoblastic cells
作者： E. R. Barnea , M. K. Sanyal , C. Brami , P. Bischof
DOI: 10.1007/BF02133780
关键词: Pregnancy-associated plasma protein A 、 Glycoprotein 、 Andrology 、 Cycloheximide 、 Explant culture 、 Decidua 、 Trophoblast 、 Endocrinology 、 In vivo 、 Biology 、 In vitro 、 Internal medicine
摘要: Pregnancy-associated plasma protein-A (PAPP-A) a high molecular weight glycoprotein, is found in concentration the maternal circulation during pregnancy. Immunohistochemically, PAPP-A can be localized trophoblast and decidua. Short term cultures of trophoblastic decidual explants produce vitro. It was thus interest to see if long primary monolayers human cells were capable producing PAPP-A. Under our vitro conditions, both βhCG. During first 3 days culture levels increased medium whereas βhCG decreased. The production proteins could inhibited by cycloheximide. These results strongly suggest that source vivo.
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