The therapeutic potential of microRNAs: disease modulators and drug targets.

摘要: MiRNAs are a class of small, naturally occurring RNA molecules that play critical roles in modulating numerous biological pathways by regulating gene expression. The knowledge miRNA expression is dysregulated many pathological disease processes, including cancer, has led to rapidly expanding body literature as we try unveil their mechanism action. Their putative role oncogenes or tumour suppressor genes presents wonderful opportunity provide targeted cancer treatment strategies. Additionally, documented function host benign diseases broadens the potential market for miRNA-based therapeutics. present review outlines underlying rationales considering mi(cro)RNAs therapeutic agents targets. We highlight manipulating miRNAs common diseases, particularly cancers. Finally, summarize challenges need be overcome fully harness therapies so they become next generation pharmaceutical products.