Opportunities and challenges of next-generation DNA sequencing for breast units.

摘要: Background The aim of this review is to introduce the topic next-generation DNA sequencing, a new technology that being introduced into clinical practice, and explain potential impact for breast cancer surgeons wider multidisciplinary team. Methods The PubMed database was used identify relevant studies relating genetics. This evidence then provide context background information demonstrate how sequencing (NGS) might change practice. Results With NGS, clinicians will know whether their patients carry high-risk mutations in genes, such as BRCA1 or BRCA2, before start treatment. could alter treatment decisions; instance, more women opt mastectomy instead breast-conserving surgery, bilateral rather than unilateral surgery. Conclusion The introduction NGS have significant on services near future. Speed testing improve regions world where adopted place conventional and, costs decrease, genetic also become accessible realistic less well funded health economies. create opportunities patient challenges team.