High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

作者: S. Rottenberg , J. E. Jaspers , A. Kersbergen , E. van der Burg , A. O. H. Nygren

DOI: 10.1073/PNAS.0806092105

关键词:

摘要: … In addition, xenografts in immunodeficient mice do not sufficiently mimic the tumor–… inhibition in a more realistic BRCA1-deficient mammary tumor model, we tested the PARP inhibitor …

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