L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential.

摘要: In human neuroblastoma cell cultures, non-human primates and beings, L-serine is neuroprotective, acting through a variety of biochemical molecular mechanisms. Although generally classified as non-essential amino acid, it probably more appropriate to term "conditional acid" since, under certain circumstances, vertebrates cannot synthesize in sufficient quantities meet necessary cellular demands. biosynthesized the mammalian central nervous system from 3-phosphoglycerate serves precursor for synthesis acids glycine cysteine. Physiologically, has roles, perhaps most importantly phosphorylation site proteins. Mutations metabolic enzymes that have been implicated various diseases. Dosing animals with clinical trials investigating therapeutic effects support FDA's determination regarded safe (GRAS); also appears be neuroprotective. We here consider role neurological disorders its potential agent.