Transport systems of serine at the brain barriers and in brain parenchymal cells
作者： Yasuyuki Kasai , Masanori Tachikawa , Shirou Hirose , Shin-ichi Akanuma , Ken-ichi Hosoya
DOI: 10.1111/J.1471-4159.2011.07313.X
关键词: Biochemistry 、 Central nervous system 、 Interstitial fluid 、 Biology 、 Cell biology 、 Blood–brain barrier 、 Transporter 、 Cerebrum 、 Glutamate receptor 、 Choroid plexus 、 NMDA receptor
摘要: D-Serine is a co-agonist for NMDA-type glutamate receptors. Although D-serine levels in CSF and interstitial fluid (ISF) affect CNS function, the regulatory system remains to be fully understood. Therefore, purpose of this study was investigate d-serine transport across blood-brain barrier (BBB) blood-CSF (BCSFB) brain parenchymal cells. microinjected into cerebrum not eliminated, suggesting negligible contribution efflux at BBB. In contrast, taken up from circulating blood BBB via carrier-mediated process. elimination clearance fourfold greater than that d-mannitol, which considered reflect bulk flow. The characteristics uptake by isolated choroid plexus were consistent with those Na(+)-independent alanine-serine-cysteine transporter 1 (asc-1). Uptake slices appeared occur predominantly asc-1 Na(+)-dependent 2. These findings suggest ISF involves (i) BCSFB, acting as major pathway CSF, (ii) blood-to-brain blood-to-CSF influx (iii) concentrative
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