Serine 403-phosphorylated p62/SQSTM1 immunoreactivity in inclusions of neurodegenerative diseases
作者： Masaru Kurosawa , Gen Matsumoto , Hiroyuki Sumikura , Hiroyuki Hatsuta , Shigeo Murayama
DOI: 10.1016/J.NEURES.2015.08.002
关键词:
摘要: Protein inclusions in neurodegenerative diseases are associated with p62, which has an important role autophagic clearance of polyubiquitinated proteins. Selective autophagy is regulated by S403-phosphorylation and S403-phosphorylated p62 (S403-phos-p62) accumulates Atg5 conditional knockout (Atg5CKO) mice autophagosome formation impaired. We performed immunohistochemical tests for the presence S403-phos-p62 postmortem brain disease cases, found accumulations amyotrophic lateral sclerosis Alzheimer's tissues. In Atg5CKO HD190QG (Huntington's model) mice, however, we a decrease immunoreactivity, suggesting that post-mortem changes should be considered when interpreting human data.
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