Complex diseases in gastroenterology and hepatology: GERD, Barrett's, and esophageal adenocarcinoma.

摘要: Gastroesophageal reflux disease, Barrett's esophagus, and esophageal adenocarcinoma are related diseases with environmental genetic determinants. The changes relevant in 2 distinct ways. First, there heritable variations germline DNA that may influence the individual susceptibility to cancer. Second, is an accumulation of somatic-cell epigenetic within epithelium during metaplasia–dysplasia–carcinoma sequence, which be important determinant for likelihood cancer progression. Esophageal occurring context a familial syndrome rare most cases sporadic. sporadic still have influences, but these likely involve multiple, low-penetrance genes. To date, relative contribution identity such genes unknown. However, future identification could public health implications patient management. With regard epithelium, map gradually being created frequently alterations. Some critical whereas others bystanders. As well as abnormalities target genes, it also possible determine global gene expression profile correlate this clinical outcome. It hoped complementary approaches will enable patients stratified terms their risk so prevention, surveillance, treatment strategies can targeted appropriately. At current time, genetics does not routine management gastroesophageal or adenocarcinoma.