Biomarkers of thyroid function and autoimmunity for predicting high-risk groups of thyroid cancer: a nested case–control study

摘要: A remarkable increase in the number of thyroid cancer cases has been reported recent years; however, markers to predict high-risk groups have not fully established. We conducted a case–control study (257 and 257 controls) that was nested Cancer Screenee Cohort Study between August 2002 December 2010; mean follow-up time for this 3.1 ± 2.2 years. The levels total triiodothyronine (TT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroglobulin (Tg), anti-thyroperoxidase antibody (TPOAb), anti-thyroglobulin (TgAb) were measured using samples with pre-diagnostic status. Logistic regression models used examine association function/autoimmunity risk. When categorized by tertile distributions control group, highest FT4 (OR = 1.73, 95% CI 1.11 - 2.69) middle TSH 1.77, 1.14 - 2.74) associated an increased risk multivariate analyses. In addition, elevated found subjects TPOAb above 30 IU/mL 8.47, 5.39 - 13.33 30–60 IU/mL OR 4.48, 2.59 - 7.76 ≥60 IU/mL). Stratified analyses indicated some these associations differed sex, BMI, smoking status, duration follow-up. This demonstrated biomarkers function/autoimmunity, particularly presence TPOAb, might be as diagnostic predicting Our findings suggest careful monitoring may helpful identifying Korean populations at cancer.