Reaction of ethyl acetoacetate with formaldehyde and primary amines
作者： D. R. Latypova , A. G. Badamshin , A. N. Lobov , V. A. Dokichev
DOI: 10.1134/S1070428013060079
关键词: Condensation 、 Chemistry 、 Aminopyridines 、 Mannich reaction 、 Formaldehyde 、 Isopropylamine 、 Primary (chemistry) 、 Methanol 、 Ethyl acetoacetate 、 Organic chemistry
摘要: The condensation of ethyl acetoacetate with formaldehyde and primary amines in methanol at 65°C (Mannich reaction) gave up to 92% hexahydropyrimidine derivatives containing ester acetyl groups. Analogous reaction aminopyridines stopped the stage formation linear products.
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