FeCl3 catalysed two consecutive aminomethylation at the α-position of the β-dicarbonyl compounds: an easy access to hexahydropyrimidines and its spiro analogues

摘要: Abstract Multicomponent synthesis of 1,3-diaryl-hexahydropyrimidines by a one-pot reaction 1,3-dicarbonyl compounds, amines and formaldehyde catalysed FeCl 3 in dichloromethane at room temperature (25–30 °C) has been reported. Double amino methylation occurs the α-position 1,3-dicabonyl compounds/β-keto esters. The same methodology leads to spiro compounds with indane-1,3-dione. In this reaction, six molecules condense one pot form new covalent bonds, thus, creating high atom economy. This is first report substituted hexahydropyrimidines involving β-keto esters its analogues