Ultrafine particle deposition and clearance in the healthy and obstructed lung.
作者： James S. Brown , Kirby L. Zeman , William D. Bennett
DOI: 10.1164/RCCM.200205-399OC
关键词: Medicine 、 Airway 、 Inhalation 、 Pathology 、 Mucociliary clearance 、 Lung 、 Ultrafine particle 、 Internal medicine 、 Respiratory disease 、 Deposition (aerosol physics) 、 Gastroenterology 、 Dose rate
摘要: Numerous epidemiologic studies have shown associations between exposure to particulate air pollution and acute increases in morbidity mortality, particularly persons with chronic obstructive pulmonary disease. The dosimetry of ultrafine particles the human lung is poorly characterized. We studied deposition clearance an technetium-99m–labeled aerosol 10 patients disease 9 healthy subjects. Particle retention was followed for 2 hours after inhalation again at 24 by γ scintigraphy. Central-to-peripheral ratios indexed airway deposition. accumulation liver examined quantifying activity below right lung. dose rate μg/m3 calculated. Patients had a significantly greater than subjects (2.9 ± 1.0 versus 1.9 0.4 μg/h, p = 0.02). were slightly (1.11 0.10 1.01 0.11...
sci-hub.se 参考文章(49)
M. Lemb, T.H. Oei, H. Eifert, B. G�nther, Technegas: a study of particle structure, size and distribution. European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 20, pp. 576- 579 ,(1993) , 10.1007/BF00176550
T. ISAWA, T. TESHIMA, Y. ANAZAWA, M. MIKI, A. M. MAHMUD, Inhalation of pertechnegas: similar clearance from the lungs to that of inhaled pertechnetate aerosol. Nuclear Medicine Communications. ,vol. 16, pp. 741- 746 ,(1995) , 10.1097/00006231-199509000-00004
J. J. Lloyd, R. A. Shields, C. J. Taylor, R. S. Lawson, J. M. James, H. J. Testra, Technegas and Pertechnegas particle size distribution. European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 22, pp. 473- 476 ,(1995) , 10.1007/BF00839062
A Peters, H E Wichmann, T Tuch, J Heinrich, J Heyder, Respiratory effects are associated with the number of ultrafine particles. American Journal of Respiratory and Critical Care Medicine. ,vol. 155, pp. 1376- 1383 ,(1997) , 10.1164/AJRCCM.155.4.9105082
A Churg, The uptake of mineral particles by pulmonary epithelial cells. American Journal of Respiratory and Critical Care Medicine. ,vol. 154, pp. 1124- 1140 ,(1996) , 10.1164/AJRCCM.154.4.8887617
Gerald C. Smaldone, W Michael Foster, Thomas G. O'Riordan, Matthew S. Messina, Robert J. Perry, Edward G. Langenback, Regional Impairment of Mucociliary Clearance in Chronic Obstructive Pulmonary Disease Chest. ,vol. 103, pp. 1390- 1396 ,(1993) , 10.1378/CHEST.103.5.1390
DAVID SINCLAIR, GEORGE S. HOOPES, A Novel Form of Diffusion Battery American Industrial Hygiene Association Journal. ,vol. 36, pp. 39- 42 ,(1975) , 10.1080/0002889758507205
Juraj Ferin, Pulmonary retention and clearance of particles. Toxicology Letters. ,vol. 72, pp. 121- 125 ,(1994) , 10.1016/0378-4274(94)90018-3
Kim A. Wales, Henry Petrow, Donovan B. Yeates, Production of 99mTc-labeled iron oxide aerosols for human lung deposition and clearance studies The International Journal of Applied Radiation and Isotopes. ,vol. 31, pp. 689- 694 ,(1980) , 10.1016/0020-708X(80)90005-8
WILLIAM M. BURCH, PAUL J. SULLIVAN, CHRISTOPHER J. MCLAREN, Technegas--a new ventilation agent for lung scanning. Nuclear Medicine Communications. ,vol. 7, pp. 865- 872 ,(1986) , 10.1097/00006231-198612000-00003