Capture probes immobilizable via l-nucleotide tail

摘要: The invention provides chimeric capture probes immobilizable via an L-nucleic acid tail that can bind to a complementary in immobilized probe. are useful for capturing target nucleic from sample. the of probe with similar affinity as would otherwise equivalent D-nucleic acids. However, and do not form stable duplexes acids present sample containing acid. Binding directly or is reduced eliminated increasing sensitivity and/or specificity assay.