Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia.
作者： Masataka Ishimura , Shouichi Ohga , Yoshihisa Nagatoshi , Jun Okamura , Tatsuro Tajiri
DOI: 10.1111/J.1399-3046.2007.00802.X
关键词: Hepatoblastoma 、 Bone marrow 、 Hepatocellular carcinoma 、 Aplastic anemia 、 Medicine 、 Bone marrow failure 、 Pathology 、 Transplantation 、 Malignancy 、 Liver tumor
摘要: A 13-yr-old boy developed post-transplant liver tumor. At three yrs of age, this patient underwent a histocompatible sibling donor BMT for severe aplastic anemia, after conditioning with antithymocyte globulin and cyclophosphamide. He became HBV carrier BMT. Stable mixed chimerism mild thrombocytopenia, but no active hepatitis continued. age 13, abdominal pain was sign massive Extremely high levels alpha-fetoprotein indicated the clinical diagnosis hepatoblastoma that might be first report as post-BMT malignancy. The necropsy specimens revealed tumor recipient cell-origin showed histopathological features both hepatocellular carcinoma. Prolonged virus infection induce rare oncogenesis non-irradiated conditioning.
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sci-hub.se 参考文章(37)
Wiwanitkit, Hepatitis virus B is not a risk factor in hepatoblastoma patients. Asian Pacific Journal of Cancer Prevention. ,vol. 6, pp. 213- 214 ,(2005)
HJ Deeg, G Socie, G Schoch, M Henry-Amar, RP Witherspoon, A Devergie, KM Sullivan, E Gluckman, R Storb, Malignancies after marrow transplantation for aplastic anemia and fanconi anemia: a joint Seattle and Paris analysis of results in 700 patients Blood. ,vol. 87, pp. 386- 392 ,(1996) , 10.1182/BLOOD.V87.1.386.386
Simone I. Strasser, Keith M. Sullivan, David Myerson, Catherine L. Spurgeon, Barry Storer, H. Gary Schoch, Carol S. Murakami, George B. McDonald, Cirrhosis of the Liver in Long-Term Marrow Transplant Survivors Blood. ,vol. 93, pp. 3259- 3266 ,(1999) , 10.1182/BLOOD.V93.10.3259.410K13_3259_3266
Akira Ohara, Seiji Kojima, Nobuyuki Hamajima, Masahiro Tsuchida, Shinsaku Imashuku, Shigeru Ohta, Hideki Sasaki, Jun Okamura, Kanji Sugita, Hisato Kigasawa, Yukio Kiriyama, Junichi Akatsuka, Ichiro Tsukimoto, Myelodysplastic syndrome and acute myelogenous leukemia as a late clonal complication in children with acquired aplastic anemia. Blood. ,vol. 90, pp. 1009- 1013 ,(1997) , 10.1182/BLOOD.V90.3.1009
S Bhatia, NK Ramsay, M Steinbuch, KE Dusenbery, RS Shapiro, DJ Weisdorf, LL Robison, JS Miller, JP Neglia, Malignant neoplasms following bone marrow transplantation. Blood. ,vol. 87, pp. 3633- 3639 ,(1996) , 10.1182/BLOOD.V87.9.3633.BLOODJOURNAL8793633
JIAAN-DER WANG, TE-KAU CHANG, HOU-CHUAN CHEN, SHENG-LING JAN, FANG-LIANG HUANG, CHING-SHIANG CHI, CHIEH-CHUNG LIN, Pediatric liver tumors : Initial presentation, image finding and outcome Pediatrics International. ,vol. 49, pp. 491- 496 ,(2007) , 10.1111/J.1442-200X.2007.02384.X
J Dumortier, T Bizollon, M Chevallier, C Ducerf, J Baulieux, J Y Scoazec, C Trepo, Recurrence of hepatocellular carcinoma as a mixed hepatoblastoma after liver transplantation Gut. ,vol. 45, pp. 622- 625 ,(1999) , 10.1136/GUT.45.4.622
Debra L. Friedman, Wendy Leisenring, Jeffrey L. Schwartz, H. Joachim Deeg, Second malignant neoplasms following hematopoietic stem cell transplantation. International Journal of Hematology. ,vol. 79, pp. 229- 234 ,(2004) , 10.1532/IJH97.03178
W-Y Au, E C Chan, A Pang, A K W Lie, R Liang, A P W Yuen, T W H Shek, Y-L Kwong, Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring Bone Marrow Transplantation. ,vol. 34, pp. 981- 985 ,(2004) , 10.1038/SJ.BMT.1704674
Jerald P. Radich, Olga Sala-Torra, Colleen Hanna, Michael R. Loken, Mary E.D. Flowers, Michael Maris, Paula A. Ladne, James R. Mason, David Senitzer, Roberto Rodriguez, Stephen J. Forman, H. Joachim Deeg, Evidence of donor-derived hematologic malignancies after hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation. ,vol. 12, pp. 511- 517 ,(2006) , 10.1016/J.BBMT.2006.01.006