Recurrence of hepatocellular carcinoma as a mixed hepatoblastoma after liver transplantation
作者： J Dumortier , T Bizollon , M Chevallier , C Ducerf , J Baulieux
DOI: 10.1136/GUT.45.4.622
关键词: Cirrhosis 、 Transplantation 、 Liver transplantation 、 Pathology 、 Population 、 Cytokeratin 、 Hepatoblastoma 、 Hepatocellular carcinoma 、 Alcoholic liver disease 、 Medicine
摘要: BACKGROUND—Hepatoblastoma is an exceptional cause of primary malignant liver tumour in the adult. PATIENT—The case reported adult patient transplanted for alcoholic cirrhosis complicated by multifocal hepatocellular carcinoma whom a recurrence form mixed hepatoblastoma invading whole developed three months after transplantation. METHODS—Complete clinical, histopathological, and immunohistochemical data were reviewed. RESULTS—The recurrent invaded liver. The major component was hepatoblastoma, with epithelial expressing cytokeratin mesenchymal vimentin. also contained minor hepatocarcinomatous α fetoprotein. rapid growth prevented any attempt at treatment. Although direct evidence lacking, most likely hypothesis to explain observations marked phenotypic change initial population recurrence. CONCLUSION—This supports possible filiation between adults. Keywords: hepatoblastoma; carcinoma; liver; transplantation
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