Association of Hormone-Replacement Therapy with Various Cardiovascular Risk Factors in Postmenopausal Women
作者： Azmi A. Nabulsi , Aaron R. Folsom , Alice White , Wolfgang Patsch , Gerardo Heiss
DOI: 10.1056/NEJM199304153281501
关键词: Hormone replacement therapy (menopause) 、 Estrogen 、 Internal medicine 、 Medicine 、 Population 、 Progestin 、 Risk factor 、 Insulin 、 Hormone 、 Endocrinology 、 Menopause
摘要: Background Most epidemiologic studies of cardiovascular disease in postmenopausal women suggest that estrogen-replacement therapy has a protective effect. The effects the use estrogen combined with progestin are less well studied. Methods To examine associations hormone-replacement concentrations plasma lipids and hemostatic factors, fasting serum glucose insulin, blood pressure, we studied 4958 participating population-based investigation. Using cross-sectional data, classified into four groups according to their therapy: current users alone, progestin, nonusers who had formerly used these hormones, never them. Results Current higher mean levels high-density lipoprotein cholesterol, its subfractions lipoprotein2 lipoprotein3, apolipoprotein A-I than nonusers, lower me...
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