Marked increase of plasma hyaluronan after major thermal injury and infusion therapy.

摘要: Hyaluronan (HYA) is an important structural element in skin and presumably participating regulation of the interstitial fluid volume. HYA transported via lymphatics from tissues to blood, where its concentration normally very low. Fluid flux through interstitium markedly increased after thermal injury. The present study was performed determine whether major injury would affect plasma levels HYA. In halothane-anesthetized sheep subjected 40% BSA full-thickness scald burns, 116 ± 19 (mean SEM) 172 18 ng/ml within 1 hr (P < 0.05). After 3 therapy further elevated 10 times baseline (1417 322 ng/ml) 0.01). To clarify this rise represented “washout” HYA, attributable either burn or subsequent therapy, awake were overhydration. Following a 3-hr infusion lactated Ringer's 2.5 liter/hr, 2–3 baseline. Lung lymph flow increased, leading increase lymphatic 10–20 peripheral Infusion removal However, concentrations higher than following challenge alone, suggesting that per se may also input into systemic circulation.