A pharmacokinetic model of intravenously administered hyaluronan in sheep.
作者： Lena Lebel , J. Robert E. Fraser , Wayne S. Kimpton , Johan Gabrielsson , Bengt Gerdin
关键词: Metabolism 、 Extraction ratio 、 Pharmacokinetics 、 Chromatography 、 Hyaluronic acid 、 Receptor 、 Michaelis–Menten kinetics 、 Lymph 、 Biochemistry 、 Chemistry 、 Microgram
摘要: Hyaluronan (HA: hyaluronic acid) is produced in the interstitium and reaches blood circulation through lymph. It rapidly eliminated by means of specific receptors on liver endothelium. The elimination characteristics intravenously administered HA were studied 10 conscious sheep at normal plasma concentration injection a 3H-labeled tracer very high an i.v. infusion unlabeled simultaneous dose HA. At (0.12 +/- 0.05 microgram/ml; range, 0.072-0.228 microgram/ml), apparent T 1/2 3H-HA was 5.3 1.1 min (range, 3.3-6.5 min). higher concentrations 1.83-3.35 micrograms/ml), considerably prolonged 18.2-43.5 A one-compartment, nonlinear model fitted to data obtained from bolus-infusion study Michaelis-Menten constant, Km, 0.12 0.04 microgram/ml, indicating that deviation linear kinetics will occur when exceeded. Vmax 0.062 0.009 microgram/ml/min. Three-dimensional surface plots showed total hepatic flow influence metabolic clearance, extraction ratio, turnover, injected hyaluronan. There correlation between as measured calculated (r = 0.96).
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sci-hub.se 参考文章(25)
B Smedsrød, H Pertoft, S Eriksson, J R E Fraser, T C Laurent, Studies in vitro on the uptake and degradation of sodium hyaluronate in rat liver endothelial cells Biochemical Journal. ,vol. 223, pp. 617- 626 ,(1984) , 10.1042/BJ2230617
J R F Fraser, T C Laurent, H Pertoft, E Baxter, Plasma clearance, tissue distribution and metabolism of hyaluronic acid injected intravenously in the rabbit Biochemical Journal. ,vol. 200, pp. 415- 424 ,(1981) , 10.1042/BJ2000415
Torvard C. Laurent, Inger Marie S. Dahl, Lauritz B. Dahl, Anna Engström-Laurent, Sigbritt Eriksson, J. Robert E. Fraser, Kirsti A. Granath, Claude Laurent, Ulla B. G. Laurent, Karin Lilja, HÅKan Pertoft, BÅRd Smedsrød, Anders Tengblad, Ove Wik, The Catabolic Fate of Hyaluronic Acid Connective Tissue Research. ,vol. 15, pp. 33- 41 ,(1986) , 10.3109/03008208609001971
A Engstrom-Laurent, R Hallgren, Circulating hyaluronate in rheumatoid arthritis: relationship to inflammatory activity and the effect of corticosteroid therapy. Annals of the Rheumatic Diseases. ,vol. 44, pp. 83- 88 ,(1985) , 10.1136/ARD.44.2.83
K N Antonas, J R Fraser, K D Muirden, Distribution of biologically labelled radioactive hyaluronic acid injected into joints. Annals of the Rheumatic Diseases. ,vol. 32, pp. 103- 111 ,(1973) , 10.1136/ARD.32.2.103
Anna Engström-Laurent, Ulla B. G. Laurent, Karin Lilja, Torvard C. Laurent, Concentration of sodium hyaluronate in serum. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 45, pp. 497- 504 ,(1985) , 10.3109/00365518509155249
V Elizabeth Hodgetts, The dynamic red cell storage function of the spleen in sheep. III. Relationship to determination of blood volume, total red cell volume, and plasma volume. Immunology and Cell Biology. ,vol. 39, pp. 187- 196 ,(1961) , 10.1038/ICB.1961.19
W.B. RUNCIMAN, A.H. ILSLEY, L.E. MATHER, R. CARAPETIS, M.M. RAO, A SHEEP PREPARATION FOR STUDYING INTERACTIONS BETWEEN BLOOD FLOW AND DRUG DISPOSITION. I: PHYSIOLOGICAL PROFILE BJA: British Journal of Anaesthesia. ,vol. 56, pp. 1015- 1028 ,(1984) , 10.1093/BJA/56.9.1015
Norman Richard Draper, Harry Smith, Applied Regression Analysis ,(1966)
J. R. E. Fraser, T. C. Laurent, A. Engström-Laurent, U. G. B. Laurent, ELIMINATION OF HYALURONIC ACID FROM THE BLOOD STREAM IN THE HUMAN Clinical and Experimental Pharmacology and Physiology. ,vol. 11, pp. 17- 25 ,(1984) , 10.1111/J.1440-1681.1984.TB00235.X